Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

Damage to DNA and RNA caused by oxidative mechanisms has been well-studied for its
potential role in the development of human disease. Only recently, though, have we begun …

When talking about research, I must mention Mrs. Rita Wagner, a superb technician that
looked after my laboratory and the younger Ph. D. students for about 25 years. Some of her …

Inert CrH bond functionalization is usually performed by dioxygen-utilizing enzymes through
the insertion of an oxygen atom into the CrH bond. Alternative reactions include …

The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book
The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the …

Abasic lesions are a family of DNA modifications that lack Watson–Crick bases. The parent
member of this family, the apurinic/apyrimidinic lesion (AP), occurs as an intermediate …

Reactive and redox-active polycyclic aromatic hydrocarbon (PAH) o-quinones produced by
Aldo-Keto Reductases (AKRs) have the potential to cause depurinating adducts leading to …

Apurinic/apyrimidinic (AP) sites are abundant DNA lesions arising from spontaneous
hydrolysis of the N-glycosidic bond and as base excision repair (BER) intermediates. AP …

This review will summarize our structural and kinetic studies of RB69 DNA polymerase
(RB69pol) as well as selected variants of the wild-type enzyme that were undertaken to …

5, 6-Dihydro-2 '-deoxyuridin-6-yl (1) was independently generated via photolysis of 3. The
radical is an analogue of the major reactive species produced from thymidine upon reaction …