[HTML][HTML] miRNA: a promising therapeutic target in cancer

A Menon, N Abd-Aziz, K Khalid, CL Poh… - International journal of …, 2022 - mdpi.com
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …

[HTML][HTML] Small molecule recognition of disease-relevant RNA structures

SM Meyer, CC Williams, Y Akahori, T Tanaka… - Chemical Society …, 2020 - pubs.rsc.org
Targeting RNAs with small molecules represents a new frontier in drug discovery and
development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir …

[HTML][HTML] Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction

G Cai, G Cai, H Zhou, Z Zhuang, K Liu, S Pei… - Stem Cell Research & …, 2021 - Springer
Background Cerebral infarction ranks as the second leading cause of disability and death
globally, and inflammatory response of glial cells is the main cause of brain damage during …

dbDEMC 3.0: functional exploration of differentially expressed miRNAs in cancers of human and model organisms

F Xu, Y Wang, Y Ling, C Zhou, H Wang… - Genomics …, 2022 - academic.oup.com
M icroRNAs (miRNAs) are important regulators in gene expression. The dysregulation of
miRNA expression is widely reported in the transformation from physiological to pathological …

MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapies

M Panda, E Kalita, S Singh, K Kumar, A Rao… - Life Sciences, 2022 - Elsevier
COVID-19 is a highly transmissible disease caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), affects 226 countries and continents, and has resulted in> 6.2 …

[HTML][HTML] MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome

W Tan, F Dai, D Yang, Z Deng, R Gu, X Zhao… - Frontiers in …, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in
women of reproductive age. miR-93-5p has been reported to be elevated in granulosa cells …

Artificial miRNAs as therapeutic tools: Challenges and opportunities

A Kotowska‐Zimmer, M Pewinska… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
RNA interference (RNAi) technology has been used for almost two decades to study gene
functions and in therapeutic approaches. It uses cellular machinery and small, designed …

The emerging role of miRNA clusters in breast cancer progression

A Kandettu, R Radhakrishnan, S Chakrabarty… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Micro RNAs (miRNAs) are small non-coding RNAs that are essential for regulation of gene
expression of the target genes. Large number of miRNAs are organized into defined units …

[HTML][HTML] Neuroinflammation in ischemic stroke: focus on microRNA-mediated polarization of microglia

L Lian, Y Zhang, L Liu, L Yang, Y Cai… - Frontiers in Molecular …, 2021 - frontiersin.org
Ischemic stroke is one of the most common causes of death and disability worldwide.
Neuroinflammation is a major pathological event involved in the process of ischemic injury …

Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals

BT Jones, J Han, H Zhang, RE Hammer… - Genes & …, 2023 - genesdev.cshlp.org
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical
roles in development and disease. Target-directed miRNA degradation (TDMD), a pathway …