Abstract Background Neural stem cells (NSCs), especially human NSCs, undergo cellular
senescence characterized by an irreversible proliferation arrest and loss of stemness after …

Multiple sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative
disease of the central nervous system, is today a leading cause of unpredictable lifelong …

There is strong evidence that aging is associated with an increased presence of senescent
cells in the brain. The finding that treatment with senolytic drugs improves cognitive …

Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age,
as well as after recurrent demyelination. Using RNA-sequencing to compare the gene …

Oligodendrogenesis is essential for replacing worn-out oligodendrocytes, promoting myelin
plasticity, and for myelin repair following a demyelinating injury in the adult mammalian …

The advent of cellular reprogramming technology converting somatic cells into induced
pluripotent stem cells (iPSCs) has revolutionized our understandings of neurodegenerative …

Normal neurodevelopment relies on intricate signaling pathways that balance neural stem
cell (NSC) self-renewal, maturation, and survival. Disruptions lead to neurodevelopmental …

In recent years, the direct interaction between cancer cells and tumor microenvironment
(TME) has emerged as a crucial regulator of tumor growth and a promising therapeutic …

Cellular stress responses influence cell fate decisions. Apoptosis and proliferation represent
opposing reactions to cellular stress or damage and may influence distinct health outcomes …

Aging is a broad process that occurs as a time-dependent functional decline and tissue
degeneration in living organisms. On a smaller scale, aging also exists within organs …