[HTML][HTML] Utilizing hiPSC-derived oligodendrocytes to study myelin pathophysiology in neuropsychiatric and neurodegenerative disorders.

G Shim, AI Romero-Morales, SR Sripathy… - Frontiers in Cellular …, 2024 - frontiersin.org
Oligodendrocytes play a crucial role in our central nervous system (CNS) by myelinating
axons for faster action potential conduction, protecting axons from degeneration, structuring …

Promise and perspective of nanomaterials in antisenescence tissue engineering applications

ZF Lu, G Singh, P Lesani, H Zreiqat - ACS Biomaterials Science & …, 2022 - ACS Publications
The tissue engineering approach for repair and regeneration has achieved significant
progress over the past decades. However, challenges remain in developing strategies to …

Remyelination therapies for multiple sclerosis: optimizing translation from animal models into clinical trials

R Sutiwisesak, TC Burns, M Rodriguez… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is the most common inflammatory disease of the central
nervous system (CNS). Demyelination, the main pathology in MS, contributes to clinical …

Considering patient age when treating multiple sclerosis across the adult lifespan

D Jakimovski, SP Eckert, R Zivadinov… - Expert Review of …, 2021 - Taylor & Francis
Introduction: The successful development of anti-inflammatory disease-modifying treatments
(DMT) significantly improved disease outcomes and longevity of persons with multiple …

[HTML][HTML] Cellular senescence and failure of myelin repair in multiple sclerosis

PN Koutsoudaki, D Papadopoulos, PG Passias… - Mechanisms of ageing …, 2020 - Elsevier
Remyelination is a physiological response to demyelinating events aiming to restore
saltatory conduction and preserve axonal integrity. Resident oligodendrocyte precursor cells …

Senescent mesenchymal stem cells: disease mechanism and treatment strategy

Y Liu, Q Chen - Current molecular biology reports, 2020 - Springer
Abstract Purpose of Review Mesenchymal stem cells (MSCs) have been extensively studied
for therapeutic application in tissue engineering and regenerative medicine. Despite their …

[HTML][HTML] iPS-derived early oligodendrocyte progenitor cells from SPMS patients reveal deficient in vitro cell migration stimulation

L Lopez-Caraballo, J Martorell-Marugan… - Cells, 2020 - mdpi.com
The most challenging aspect of secondary progressive multiple sclerosis (SPMS) is the lack
of efficient regenerative response for remyelination, which is carried out by the endogenous …

[HTML][HTML] Using MS induced pluripotent stem cells to investigate MS aetiology

AJ Fortune, JL Fletcher, NB Blackburn… - Multiple Sclerosis and …, 2022 - Elsevier
Multiple sclerosis (MS) is a complex disease, and its pathophysiology impacts the function of
immune and central nervous system cell types. Despite extensive investigation into the …

Glycyrrhizic acid promotes neural repair by directly driving functional remyelination

J Tian, X Li, L Zhao, P Shen, Z Wang, L Zhu, C Li… - Food & function, 2020 - pubs.rsc.org
Natural compounds are a rich source of effective candidate drugs for the treatment of
neurological disorders. Glycyrrhizic acid (GA), the major water-soluble ingredient isolated …

The influence of aging and the microbiome in multiple sclerosis and other neurologic diseases

NM Fettig, A Pu, LC Osborne… - Immunological …, 2024 - Wiley Online Library
The human gut microbiome is well‐recognized as a key player in maintaining health.
However, it is a dynamic entity that changes across the lifespan. How the microbial changes …