[HTML][HTML] Utilizing hiPSC-derived oligodendrocytes to study myelin pathophysiology in neuropsychiatric and neurodegenerative disorders.
G Shim, AI Romero-Morales, SR Sripathy… - Frontiers in Cellular …, 2024 - frontiersin.org
Oligodendrocytes play a crucial role in our central nervous system (CNS) by myelinating
axons for faster action potential conduction, protecting axons from degeneration, structuring …
axons for faster action potential conduction, protecting axons from degeneration, structuring …
Promise and perspective of nanomaterials in antisenescence tissue engineering applications
The tissue engineering approach for repair and regeneration has achieved significant
progress over the past decades. However, challenges remain in developing strategies to …
progress over the past decades. However, challenges remain in developing strategies to …
Remyelination therapies for multiple sclerosis: optimizing translation from animal models into clinical trials
R Sutiwisesak, TC Burns, M Rodriguez… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is the most common inflammatory disease of the central
nervous system (CNS). Demyelination, the main pathology in MS, contributes to clinical …
nervous system (CNS). Demyelination, the main pathology in MS, contributes to clinical …
Considering patient age when treating multiple sclerosis across the adult lifespan
D Jakimovski, SP Eckert, R Zivadinov… - Expert Review of …, 2021 - Taylor & Francis
Introduction: The successful development of anti-inflammatory disease-modifying treatments
(DMT) significantly improved disease outcomes and longevity of persons with multiple …
(DMT) significantly improved disease outcomes and longevity of persons with multiple …
[HTML][HTML] Cellular senescence and failure of myelin repair in multiple sclerosis
PN Koutsoudaki, D Papadopoulos, PG Passias… - Mechanisms of ageing …, 2020 - Elsevier
Remyelination is a physiological response to demyelinating events aiming to restore
saltatory conduction and preserve axonal integrity. Resident oligodendrocyte precursor cells …
saltatory conduction and preserve axonal integrity. Resident oligodendrocyte precursor cells …
Senescent mesenchymal stem cells: disease mechanism and treatment strategy
Abstract Purpose of Review Mesenchymal stem cells (MSCs) have been extensively studied
for therapeutic application in tissue engineering and regenerative medicine. Despite their …
for therapeutic application in tissue engineering and regenerative medicine. Despite their …
[HTML][HTML] iPS-derived early oligodendrocyte progenitor cells from SPMS patients reveal deficient in vitro cell migration stimulation
L Lopez-Caraballo, J Martorell-Marugan… - Cells, 2020 - mdpi.com
The most challenging aspect of secondary progressive multiple sclerosis (SPMS) is the lack
of efficient regenerative response for remyelination, which is carried out by the endogenous …
of efficient regenerative response for remyelination, which is carried out by the endogenous …
[HTML][HTML] Using MS induced pluripotent stem cells to investigate MS aetiology
Multiple sclerosis (MS) is a complex disease, and its pathophysiology impacts the function of
immune and central nervous system cell types. Despite extensive investigation into the …
immune and central nervous system cell types. Despite extensive investigation into the …
Glycyrrhizic acid promotes neural repair by directly driving functional remyelination
J Tian, X Li, L Zhao, P Shen, Z Wang, L Zhu, C Li… - Food & function, 2020 - pubs.rsc.org
Natural compounds are a rich source of effective candidate drugs for the treatment of
neurological disorders. Glycyrrhizic acid (GA), the major water-soluble ingredient isolated …
neurological disorders. Glycyrrhizic acid (GA), the major water-soluble ingredient isolated …
The influence of aging and the microbiome in multiple sclerosis and other neurologic diseases
The human gut microbiome is well‐recognized as a key player in maintaining health.
However, it is a dynamic entity that changes across the lifespan. How the microbial changes …
However, it is a dynamic entity that changes across the lifespan. How the microbial changes …