We present a formalism for using functional imaging both to derive patient‐specific
radiobiological properties and consequently to prescribe optimal nonuniform radiotherapy …

Even with recent advances in cancer diagnosis and therapy, treatment outcomes for many
cancers remain dismal. Patients often show different response to the same therapy regimen …

Current cancer therapy strategy is mostly population based, however, there are large
differences in tumour response among patients. It is therefore important for treating …

Hypoxia, that is, insufficient oxygen partial pressure, is a known cause of reduced
radiosensitivity in solid tumors, and especially in head-and-neck tumors. It is thus believed to …

The insulin-like growth factor (IGF) system consists of two ligands (IGF-I and IGF-II), which
both signal through IGF-I receptor (IGF-IR) to stimulate proliferation and inhibit apoptosis …

IMRT with inverse planning allows simultaneous integrated boost strategies that exploit the
heterogeneous dose distribution within the planning target volumes (PTVs). In this scenario …

Background and Purpose To estimate clinical roles of 18F-fluorodeoxyglucose (FDG)
positron emission tomography (PET) versus angiography and ultrasonography in carotid …

Purpose: There is significant current interest in the use of biological image guidance in
radiotherapy planning. In lung‐cancer treatment, tumor motion due to respiration is known to …

The quality of dosimetry in radiotherapy treatment requires the accurate delimitation of the
gross tumor volume. This can be achieved by complementing the anatomical detail provided …

Positron emission tomography (PET) is a non-invasive imaging technique based on
coincidence detection of two simultaneously emitted photons that occurs when a positron …