Research into the pathophysiology of osteoarthritis (OA) has focused on cartilage and peri-
articular bone, but there is increasing recognition that OA affects all of the joint tissues …

Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Patients with late-stage Kellgren-Lawrence knee osteoarthritis received a single intra-
articular injection of 1, 10, or 50 million bone marrow mesenchymal stromal cells (BM-MSCs) …

Osteoarthritis (OA) is a well-known disease that is part of the aging process and also one of
the most common diseases among mammals. Although this musculoskeletal disorder has …

Objective The adduction moment at the knee during gait is the primary determinant of medial‐
tolateral load distribution. If the adduction moment contributes to progression of osteoarthritis …

Hyaluronic acid is a naturally occurring Polysaccharide with distinct physicochemical
properties which underlie its application as a viscoelastic tool in ophthalmological surgery …

Osteoarthritis (OA) is currently defined by the American College of Rheumatology as a
“heterogeneous group of conditions that leads to joint symptoms and signs which are …

In a search of new bone proteins, the glycoprotein YKL-40 was identified in 1989 to be
secreted in vitro in large amount by the human osteosarcoma cell line MG63. The protein …

OBJECTIVE: C-reactive protein (CRP) has been associated with disease progression in
patients with osteoarthritis (OA), but the reasons for this remain unclear. We hypothesized …

Objective The hallmark of osteoarthritis (OA) is the loss of articular cartilage. This loss arises
from an imbalance between cartilage synthesis and cartilage degradation over a variable …