In past decades, anticancer research has led to remarkable results despite many of the
approved drugs still being characterized by high systemic toxicity mainly due to the lack of …

Unfortunately, there is no endogenous marker for hepatic clearance that can be used as a
guide for drug dosing. In order to predict the kinetic behaviour of drugs in cirrhotic patients …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

Background This study evaluates the relationship between cytochrome P450 (CYP) 3A5
genotype and vincristine‐induced peripheral neuropathy (VIPN) in children with precursor B …

Upon emergence of modern anticancer therapy, medical community is divided into two
opposite camps, one of them claiming absolute necessity of using isolated or synthesized …

With the realization of the importance of drug efflux transporters in disease processes and
treatment, development of inhibitors to these transporters has been sought for use as …

Background This report examines the association between race and vincristine‐associated
neurotoxicity in pediatric patients with precursor B cell acute lymphoblastic leukemia (preB …

Classical chemotherapeutic agents such as mitotic inhibitors (spindle poisons), alkylating
agents, antimetabolites, topoisomerase inhibitors, and anthracenediones (anthracyclines) …

Purpose: Desmoid-type fibromatosis (DF) are locally aggressive neoplasms, with a need for
effective systemic treatment in case of progression to avoid the short-and long-term …

Dosages of anticancer drugs are usually calculated on the basis of a uniform standard, the
body surface area (BSA). Although many physiological functions are proportionate to BSA …