[HTML][HTML] Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression …
A Borsini, A Nicolaou, D Camacho-Muñoz… - Molecular …, 2021 - nature.com
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can exert antidepressant,
anti-inflammatory and neuroprotective properties, but the exact molecular mechanism …
anti-inflammatory and neuroprotective properties, but the exact molecular mechanism …
[HTML][HTML] Psychological symptoms in COVID-19 patients: insights into pathophysiology and risk factors of long COVID-19
Simple Summary The coronavirus can elude the immune response, potentially spreading to
cells other than the respiratory tract's epithelial cells. The neuro-invasive potential of certain …
cells other than the respiratory tract's epithelial cells. The neuro-invasive potential of certain …
[HTML][HTML] Past, present and (foreseeable) future of biological anti-TNF alpha therapy
GM Leone, K Mangano, MC Petralia, F Nicoletti… - Journal of Clinical …, 2023 - mdpi.com
Due to the key role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of
immunoinflammatory diseases, TNF-α inhibitors have been successfully developed and …
immunoinflammatory diseases, TNF-α inhibitors have been successfully developed and …
Depression, dementia and immune dysregulation
S Hayley, AM Hakim, PR Albert - Brain, 2021 - academic.oup.com
Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …
conditions. These include stroke, cardiovascular disease, and dementia including …
Depression heterogeneity and its biological underpinnings: toward immunometabolic depression
Y Milaneschi, F Lamers, M Berk, BWJH Penninx - Biological psychiatry, 2020 - Elsevier
Epidemiological evidence indicates the presence of dysregulated homeostatic biological
pathways in depressed patients, such as increased inflammation and disrupted energy …
pathways in depressed patients, such as increased inflammation and disrupted energy …
Gut microbiota–brain axis in depression: The role of neuroinflammation
AS Carlessi, LA Borba, AI Zugno… - European Journal of …, 2021 - Wiley Online Library
Major depressive disorder (MDD) is a psychiatric condition that affects a large number of
people in the world, and the treatment existents do not work for all individuals affected. Thus …
people in the world, and the treatment existents do not work for all individuals affected. Thus …
[HTML][HTML] Biological factors influencing depression in later life: role of aging processes and treatment implications
SM Szymkowicz, AR Gerlach, D Homiack… - Translational …, 2023 - nature.com
Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …
[HTML][HTML] How inflammation affects the brain in depression: a review of functional and structural MRI studies
This narrative review discusses how peripheral and central inflammation processes affect
brain function and structure in depression, and reports on recent peripheral inflammatory …
brain function and structure in depression, and reports on recent peripheral inflammatory …
Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities
Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …
Cerebrospinal fluid biomarkers in patients with unipolar depression compared with healthy control individuals: a systematic review and meta-analysis
IV Mousten, NV Sørensen, RHB Christensen… - JAMA …, 2022 - jamanetwork.com
Importance Depression has been associated with alterations in neurotransmitters,
hormones, and inflammatory and neurodegenerative biomarkers, and biomarkers quantified …
hormones, and inflammatory and neurodegenerative biomarkers, and biomarkers quantified …