Human genomics of COVID-19 pneumonia: Contributions of rare and common variants
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …
Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer's disease
S Feng, Y Liu, Y Zhou, Z Shu, Z Cheng… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's Disease (AD) is an aging-associated neurodegenerative disorder, threatening
millions of people worldwide. The onset and progression of AD can be accelerated by …
millions of people worldwide. The onset and progression of AD can be accelerated by …
HDL-based therapeutics: A promising frontier in combating viral and bacterial infections
Low levels of high-density lipoprotein (HDL) and impaired HDL functionality have been
consistently associated with increased susceptibility to infection and its serious …
consistently associated with increased susceptibility to infection and its serious …
Autoantibodies to interferons in infectious diseases
E Quiros-Roldan, A Sottini, SG Signorini, F Serana… - Viruses, 2023 - mdpi.com
Anti-cytokine autoantibodies and, in particular, anti-type I interferons are increasingly
described in association with immunodeficient, autoimmune, and immune-dysregulated …
described in association with immunodeficient, autoimmune, and immune-dysregulated …
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity
H Li, X Wang, Y Wang, Y Li, Y Chen, YT Wong… - … and Targeted Therapy, 2023 - nature.com
The crucial role of interferon (IFN) signaling is well known in the restriction or eradication of
pathogen invasion. Viruses take a variety of ways to antagonize host defense through …
pathogen invasion. Viruses take a variety of ways to antagonize host defense through …
[HTML][HTML] Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice
Adolescent exposure to Δ 9-tetrahydrocannabinol (THC) has enduring effects on energy
metabolism and immune function. Prior work showed that daily administration of a low …
metabolism and immune function. Prior work showed that daily administration of a low …
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain
Most cases of herpes simplex virus 1 (HSV-1) encephalitis (HSE) remain unexplained,.
Here, we report on two unrelated people who had HSE as children and are homozygous for …
Here, we report on two unrelated people who had HSE as children and are homozygous for …
The role of plasmacytoid dendritic cells (pDCs) in immunity during viral infections and beyond
C Ngo, C Garrec, E Tomasello, M Dalod - Cellular & Molecular …, 2024 - nature.com
Type I and III interferons (IFNs) are essential for antiviral immunity and act through two
different but complimentary pathways. First, IFNs activate intracellular antimicrobial …
different but complimentary pathways. First, IFNs activate intracellular antimicrobial …
The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKK β and increasing the stability of …
T Wang, R Luo, J Zhang, J Lan, Z Lu… - Emerging Microbes & …, 2024 - Taylor & Francis
African swine fever (ASF) is a highly contagious, often fatal viral disease caused by African
swine fever virus (ASFV), which imposes a substantial economic burden on the global pig …
swine fever virus (ASFV), which imposes a substantial economic burden on the global pig …
Clinical and biomarker profile responses to rehabilitation treatment in patients with long COVID characterized by chronic fatigue
J Binetti, M Real, M Renzulli, L Bertran, D Riesco… - Viruses, 2023 - mdpi.com
Long COVID (LC) syndrome is a complex multiorgan symptom that persists beyond> 12
weeks after SARS-CoV-2 infection. The most frequently associated symptom is fatigue …
weeks after SARS-CoV-2 infection. The most frequently associated symptom is fatigue …