Inflammation and Macrophage Loss Mark Increased Susceptibility in a Genetic Model of Acute Viral Infection–Induced Tissue Damage

JL Annis, MG Brown - The Journal of Immunology, 2024 - journals.aai.org
M. R2 k/b mice are identical to the MA/My parent strain aside from a 5.58-Mb C57L-derived
region on chromosome 17 (Cmv5 s) that causes increased susceptibility to acute murine …

Autoantibodies against type I IFNs in patients with Ph-negative myeloproliferative neoplasms

O Borsani, P Bastard, J Rosain… - Blood, The Journal …, 2022 - ashpublications.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection displays extreme
interindividual clinical variability, ranging from asymptomatic infection to life-threatening …

Life-threatening infections in human newborns: Reconciling age-specific vulnerability and interindividual variability

A Borghesi - Cellular Immunology, 2024 - Elsevier
In humans, the interindividual variability of clinical outcome following exposure to a
microorganism is immense, ranging from silent infection to life-threatening disease. Age …

In memoriam: Stephen J Seligman, MD: adverse reactions to the yellow fever vaccine: from epidemiological risk factors to causes and mechanisms

JL Casanova, Q Zhang, P Bastard… - Journal of Clinical …, 2022 - Springer
During a conversation about life-threatening adverse reactions to the yellow fever (YF)
vaccine, Adolfo Garcia-Sastre (Professor at Mount Sinai, New York) recommended that he …

Interpretable Inflammation Landscape of Circulating Immune cells

L Jiménez-Gracia, D Maspero, S Aguilar-Fernández… - bioRxiv, 2023 - biorxiv.org
Inflammation is a biological phenomenon involved in a wide variety of physiological and
pathological processes. Although a controlled inflammatory response is beneficial for …

The role of minerals in COVID-19: an umbrella review

C Van De Venter, C Konn, M Doherty, R Purdy - CAND Journal, 2023 - candjournal.ca
Background: This umbrella review aims to synthesize the existing literature on the
preventive and therapeutic benefits of minerals zinc, selenium, iron, copper, magnesium …

Apport des techniques de séquençage de l'ADN de nouvelle génération en pratique et en recherche médicale en France

P Brousset, L Abel, P Froguel, L Quintana-Murci… - Bulletin de l'Académie …, 2024 - Elsevier
Résumé Depuis plus d'une dizaine d'années, la France a mis en place plusieurs initiatives
et programmes visant à promouvoir et à exploiter le potentiel des techniques de next …

Commensal bacteria inhibit viral infections via a tryptophan metabolite

D Jiang, N Soo, CY Tan, S Dankwa, HY Wang… - bioRxiv, 2024 - biorxiv.org
There is growing appreciation that commensal bacteria impact the outcome of viral
infections, though the specific bacteria and their underlying mechanisms remain poorly …

Translation rescue by targeting Ppp1r15a upstream open reading frame in vivo

A Kidwell, SPS Yadav, B Maier, A Zollman, K Ni… - BioRxiv, 2021 - biorxiv.org
The eIF2 initiation complex is central to maintaining a functional translation machinery.
Extreme stress such as life-threatening sepsis exposes vulnerabilities in this tightly …

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

C Ngo, K Rahmani, M Valente, N Collinet, G Bessou… - bioRxiv, 2024 - biorxiv.org
Plasmacytoid dendritic cells (pDCs) are major producers of type I/III interferons. As these
cytokines are crucial for antiviral defense, it is assumed to be also the case for pDCs …