Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

Despite improved methods of diagnosis and the development of different treatments,
mortality from lung cancer remains surprisingly high. Non-small cell lung cancer (NSCLC) …

Cross-talk between the tumor microenvironment (TME) and cancer cells plays an important
role in acquired drug resistance to epidermal growth factor receptor tyrosine kinase …

Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor
treatment. The emergence of tumor drug resistance has always been a main concern of …

Simple Summary Persistent activation of STAT3 is frequently observed in non-small cell lung
cancer and is associated with a poor prognosis. Given the multifaceted role of STAT3 …

Anti-neoplastic agents for cancer treatment utilize many different mechanisms of action and,
when combined, can result in potent inhibition of cancer growth. Combination therapies can …

Lung cancer is a common malignancy worldwide, with high morbidity and mortality. Signal
transducer and activator of transcription 3 (STAT3) is an important transcription factor that …

End-stage nasopharyngeal carcinoma (NPC) has unsatisfactory survival. The limited benefit
of chemotherapy and the scarcity of targeted drugs are major challenges in NPC. New …

Although the advent of osimertinib has brought revolutionary changes to the treatment
landscape of non-small cell lung cancer (NSCLC) patients, acquired resistance remains a …

While KRAS mutation is the leading cause of low survival rates in lung cancer bone
metastasis patients, effective treatments are still lacking. Here, we identified homeobox C10 …