Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature

M Imran, SA Khan, Abida, MK Alshammari, SM Alkhaldi… - Molecules, 2022 - mdpi.com
COVID-19 has had an impact on human quality of life and economics. Scientists have been
identifying remedies for its prevention and treatment from all possible sources, including …

[HTML][HTML] Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial

AE Koshak, EA Koshak, AF Mobeireek… - … Therapies in Medicine, 2021 - Elsevier
Abstract Background Effective treatment for Coronavirus Disease-2019 (COVID-19) is under
intensive research. Nigella sativa oil (NSO) is a herbal medicine with antiviral and …

Potential Pharmacological Applications of Nigella Seeds with a Focus on Nigella sativa and Its Constituents against Chronic Inflammatory Diseases: Progress and …

S Wahab, A Alsayari - Plants, 2023 - mdpi.com
The leading cause of death worldwide has been identified as chronic illnesses, according to
the World Health Organization (WHO). Chronic inflammatory conditions such as asthma …

Honey and Nigella sativa against COVID‐19 in Pakistan (HNS‐COVID‐PK): A multicenter placebo‐controlled randomized clinical trial

S Ashraf, S Ashraf, M Ashraf, MA Imran… - Phytotherapy …, 2023 - Wiley Online Library
Until now, no specific and effective treatment exists for coronavirus disease 2019 (COVID‐
19). Since honey and Nigella sativa (HNS) have established antiviral, antibacterial …

Antiviral electrospun polyamide three-layered mask filter containing metal oxide nanoparticles and black seed oil

NM Deyab, B Ekram, KR Badr, BM Abd El-Hady… - ACS …, 2022 - ACS Publications
Upon the tremendous spread of coronavirus, there is a need to develop biodegradable,
multifunctional, antiviral masks that can be safely used without polluting the environment as …

The effect of Ni gella sativa and vitamin D3 supplementation on the clinical outcome in COVID-19 patients: A randomized controlled clinical trial

SA Said, A Abdulbaset, AA El-Kholy… - Frontiers in …, 2022 - frontiersin.org
Background: The coronavirus disease 2019 (COVID-19) is a novel coronavirus that causes
severe infection in the respiratory system. Since the immune status plays an essential role in …

[HTML][HTML] A qualitative and quantitative comparison of Crocus sativus and Nigella sativa immunomodulatory effects

MR Khazdair, Z Gholamnezhad, R Rezaee… - Biomedicine & …, 2021 - Elsevier
The present article reviews and compares the immunomodulatory activities of Crocus
sativus (C. sativus) and Nigella sativa (N. sativa) and their main bioactive compounds …

Antiviral potential of small molecules cordycepin, thymoquinone, and N6, N6-dimethyladenosine targeting SARS-CoV-2 entry protein ADAM17

J He, S Liu, Q Tan, Z Liu, J Fu, T Li, C Wei, X Liu, Z Mei… - Molecules, 2022 - mdpi.com
COVID-19 is an acute respiratory disease caused by SARS-CoV-2 that has spawned a
worldwide pandemic. ADAM17 is a sheddase associated with the modulation of the receptor …

Novel thymoquinone nanoparticles using poly (ester amide) based on L-arginine-targeting pulmonary drug delivery

EZ Dahmash, DK Ali, HS Alyami, H AbdulKarim… - Polymers, 2022 - mdpi.com
Thymoquinone (TQ), the main active constituent of Nigella sativa, has demonstrated broad-
spectrum antimicrobial, antioxidant, and anti-inflammatory effects, which suggest its potential …

Oral thymoquinone modulates cyclophosphamide‐induced testicular toxicity in adolescent Wistar rats

MY Adana, A Imam, AA Bello, OE Sunmonu… - Andrologia, 2022 - Wiley Online Library
Cyclophosphamide (CYP) is an effective anti‐cancer drug that is widely accepted, but it is
not devoid of unintended toxic effects. Gonadal toxicity is reported as one of the side effects …