Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
SCS Brandao, JOX Ramos, LT Dompieri… - Cytokine & Growth …, 2021 - Elsevier
The severe form of COVID-19 is marked by an abnormal and exacerbated immunological
host response favoring to a poor outcome in a significant number of patients, especially …
host response favoring to a poor outcome in a significant number of patients, especially …
Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists
S Federico, L Pozzetti, A Papa, G Carullo… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
TLR4-targeting therapeutics: structural basis and computer-aided drug discovery approaches
The integration of computational techniques into drug development has led to a substantial
increase in the knowledge of structural, chemical, and biological data. These techniques are …
increase in the knowledge of structural, chemical, and biological data. These techniques are …
Increasing the chemical variety of small-molecule-based TLR4 modulators: An overview
Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by
Pathogen-and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers …
Pathogen-and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers …
Targeting cellular and tissue HIV reservoirs with toll-like receptor agonists
The elimination of both cellular and tissue latent reservoirs is a challenge toward a
successful HIV cure.“Shock and Kill” are among the therapeutic strategies that have been …
successful HIV cure.“Shock and Kill” are among the therapeutic strategies that have been …
Postulated adjuvant therapeutic strategies for COVID-19
AO Ferreira, HC Polonini, ECF Dijkers - Journal of Personalized Medicine, 2020 - mdpi.com
The number of COVID-19 patients is still growing exponentially worldwide due to the high
transmissibility of the SARS-CoV-2 virus. Therapeutic agents currently under investigation …
transmissibility of the SARS-CoV-2 virus. Therapeutic agents currently under investigation …
Effects of UV/H2O2 degradation and step gradient ethanol precipitation on Sargassum fusiforme polysaccharides: Physicochemical characterization and protective …
In this study, the degraded purified fraction from Sargassum fusiforme polysaccharides
(SFP), named DSFP, was produced by the treatment of ultraviolet/hydrogen peroxide (UV/H …
(SFP), named DSFP, was produced by the treatment of ultraviolet/hydrogen peroxide (UV/H …
Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury
Z Hu, R Du, L Xiu, Z Bian, C Ma, N Sato, M Hattori… - Cytokine, 2020 - Elsevier
Ganoderma lucidum is a popular medicinal mushroom, which has been used as therapeutic
for centuries in traditional Chinese medicine. Although G. lucidum showed strong protective …
for centuries in traditional Chinese medicine. Although G. lucidum showed strong protective …
Anti-inflammatory and antioxidant effects of Chaetoglobosin Vb in LPS-induced RAW264. 7 cells: Achieved via the MAPK and NF-κB signaling pathways
H Zhang, Q Guo, Z Liang, M Wang, B Wang… - Food and Chemical …, 2021 - Elsevier
There are few reports on the biological activities of chaetoglobosin V b (Cha V b)(a
cytochalasin alkaloid). In this study, we investigated the molecular mechanisms underlying …
cytochalasin alkaloid). In this study, we investigated the molecular mechanisms underlying …
Toll-like receptor 4 is a key regulator of asthma exacerbation caused by aluminum oxide nanoparticles via regulation of NF-κB phosphorylation
JO Lim, WI Kim, SW Pak, SJ Lee, SH Park… - Journal of Hazardous …, 2023 - Elsevier
Aluminum oxide nanoparticles (Al 2 O 3 NPs) have recently been reported to cause an
inflammatory response in the lungs, and studies are being conducted on their adverse …
inflammatory response in the lungs, and studies are being conducted on their adverse …