Breast cancer is the most common malignancy among females. 5%–10% of breast cancer
cases are hereditary and are caused by pathogenic mutations in the considered reference …

Women at high risk of developing breast cancer are a heterogeneous group of women
including those with and without high-risk germline mutation/s. Prevention in these women …

Breast cancer is a global burden with a woman's lifetime risk of developing breast cancer at
1 in 8. Although breast cancer is a disease that affects mostly women, the lifetime risk in men …

Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2,
associated with Hereditary Breast & Ovarian Cancer syndrome, have up to an 85% lifetime …

New evidence on breast Magnetic Resonance Imaging (MRI) screening has become
available since the American Cancer Society (ACS) last issued guidelines for the early …

The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage
and mutation analysis in 237 families, each with at least four cases of breast cancer …

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …

Interpreting variants of uncertain significance (VUS) is a central challenge in medical
genetics. One approach is to experimentally measure the functional consequences of VUS …

Grain weight is one of the most important components of grain yield and is controlled by
quantitative trait loci (QTLs) derived from natural variations in crops. However, the molecular …

Zinc ions are key structural components of a large number of proteins. The binding of zinc
stabilizes the folded conformations of domains so that they may facilitate interactions …