Chemical design of activatable photoacoustic probes for precise biomedical applications

Y Liu, L Teng, B Yin, H Meng, X Yin, S Huan… - Chemical …, 2022 - ACS Publications
Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …

Why nature chose selenium

HJ Reich, RJ Hondal - ACS chemical biology, 2016 - ACS Publications
The authors were asked by the Editors of ACS Chemical Biology to write an article titled
“Why Nature Chose Selenium” for the occasion of the upcoming bicentennial of the …

[HTML][HTML] An activity-guided map of electrophile-cysteine interactions in primary human T cells

EV Vinogradova, X Zhang, D Remillard, DC Lazar… - Cell, 2020 - cell.com
Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …

[HTML][HTML] Amino acid catabolism in plants

TM Hildebrandt, AN Nesi, WL Araújo, HP Braun - Molecular plant, 2015 - cell.com
Amino acids have various prominent functions in plants. Besides their usage during protein
biosynthesis, they also represent building blocks for several other biosynthesis pathways …

The redox code

DP Jones, H Sies - Antioxidants & redox signaling, 2015 - liebertpub.com
Significance: The redox code is a set of principles that defines the positioning of the
nicotinamide adenine dinucleotide (NAD, NADP) and thiol/disulfide and other redox systems …

Synthesis versus degradation: directions of amino acid metabolism during Arabidopsis abiotic stress response

TM Hildebrandt - Plant molecular biology, 2018 - Springer
Key message During abiotic stress low abundant amino acids are not synthesized but they
accumulate due to increased protein turnover under conditions inducing carbohydrate …

[HTML][HTML] Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery

CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

[HTML][HTML] Role of metabolic H2O2 generation: redox signaling and oxidative stress

H Sies - Journal of Biological Chemistry, 2014 - ASBMB
Hydrogen peroxide, the nonradical 2-electron reduction product of oxygen, is a normal
aerobic metabolite occurring at about 10 nm intracellular concentration. In liver, it is …

Oxidative stress

H Sies, C Berndt, DP Jones - Annual review of biochemistry, 2017 - annualreviews.org
Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to
biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative …

[HTML][HTML] Arsenic binding to proteins

S Shen, XF Li, WR Cullen, M Weinfeld, XC Le - Chemical reviews, 2013 - ACS Publications
Arsenic is a trace element found in the earth, s crust at an average concentration of∼ 5 μg/g
(ppm). Although its relative abundance in the earth, s crust is about 54th, arsenic can …