The modification of proteins with non‐protein entities is important for a wealth of
applications, and methods for chemically modifying proteins attract considerable attention …

A radical is any molecule that contains one or more unpaired electrons. Radicals are normal
products of many metabolic pathways. Some exist in a controlled (caged) form as they …

Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …

The biological activity of selenium is dependent upon its speciation. We aim to integrate
selenium speciation and metabolism into a discussion of the mechanisms by which …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

Zinc and cellular oxidants such as reactive oxygen species (ROS) each participate in a
multitude of physiological functions. There is considerable overlap between the affected …

Bioconjugation chemistry has been used to prepare modified biomolecules with functions
beyond what nature intended. Central to these techniques is the development of highly …

Hydrogen sulfide (H 2 S) is an endogenously generated and putative signaling/effector
molecule. Despite its numerous reported functions, the chemistry by which it elicits its …

This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …

Diets comprising selenium-deficient crops have been linked to immune disorders and
cardiomyopathy. Selenium nanoparticles (SeNPs) have emerged as a promising …