BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …

Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …

Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …

Male infertility is an attracting growing concern owing to decline in sperm quality of men
worldwide. Phthalates, in particular to di (2-ethylhexyl) phthalate (DEHP) or its main …

It is well-established that testicular spermatozoa are immature and acquire motility and
fertilization capabilities during transit throughout the epididymis. The epididymis is a duct …

Infertility is defined as the inability of couples to have a baby after one year of regular
unprotected intercourse, affecting 10 to 15% of couples. According to the latest WHO …

Objective To identify cell types in the male and female reproductive systems at risk for SARS-
CoV-2 infection because of the expression of host genes and proteins used by the virus for …

Mammalian male germ-cell development consists of three distinct phases: primordial germ
cell (PGC) development, male germ-cell specification for spermatogonium development …

Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells
(SSCs) produce haploid spermatozoa. This highly specialized process is precisely …

A systematic interrogation of male germ cells is key to complete understanding of molecular
mechanisms governing spermatogenesis and the development of new strategies for …