Studies using induced pluripotent stem cells (iPSCs) are gaining momentum in brain
disorder modelling, but optimal study designs are poorly defined. Here, we compare …

The neurovascular unit (NVU), consisting of neurons, glial cells, vascular cells (endothelial
cells, pericytes and vascular smooth muscle cells (VSMCs)) together with the surrounding …

ELAV/Hu factors are conserved RNA binding proteins (RBPs) that play diverse roles in
mRNA processing and regulation. The founding member, Drosophila Elav, was recognized …

Although splicing occurs largely co-transcriptionally, the order by which introns are removed
does not necessarily follow the order in which they are transcribed. Whereas several …

Objective: Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease
that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The …

NMDA receptors (NMDARs), a prominent subtype of glutamatergic receptors, are implicated
in the pathogenesis and development of neuropsychiatric disorders such as epilepsy …

The RNA isoform repertoire is regulated by splicing factor (SF) expression, and alterations in
SF levels are associated with disease. SFs contain ultraconserved poison exon (PE) …

Neurodegenerative diseases are a group of debilitating pathologies in which neuronal
tissue dies due to the buildup of neurotoxic plaques, resulting in detrimental effects on …

Abstract Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat
bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of …

Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular
models of psychiatric disorders that account for a patient's genetic background. Here, we …