[PDF][PDF] Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation
Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic
element in both humans and mice, comprising almost 20% of each genome. L1s are …
element in both humans and mice, comprising almost 20% of each genome. L1s are …
[HTML][HTML] Using multi-organ culture systems to study Parkinson's disease
In recent years, it has been revealed that Parkinson's disease pathology may begin to
manifest in the gastrointestinal track at a much earlier time point than in the brain. This …
manifest in the gastrointestinal track at a much earlier time point than in the brain. This …
[HTML][HTML] Human pluripotent stem-cell-derived models as a missing link in drug discovery and development
X Lin, J Tang, YR Lou - Pharmaceuticals, 2021 - mdpi.com
Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and
human-induced pluripotent stem cells (hiPSCs), have the potential to accelerate the drug …
human-induced pluripotent stem cells (hiPSCs), have the potential to accelerate the drug …
[HTML][HTML] SPEAQeasy: a scalable pipeline for expression analysis and quantification for R/bioconductor-powered RNA-seq analyses
Background RNA sequencing (RNA-seq) is a common and widespread biological assay,
and an increasing amount of data is generated with it. In practice, there are a large number …
and an increasing amount of data is generated with it. In practice, there are a large number …
[HTML][HTML] Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis
F Mastropasqua, M Oksanen, C Soldini… - Biology …, 2023 - journals.biologists.com
ABSTRACT Genetic variants affecting Heterogeneous Nuclear Ribonucleoprotein U
(HNRNPU) have been identified in several neurodevelopmental disorders (NDDs) …
(HNRNPU) have been identified in several neurodevelopmental disorders (NDDs) …
[HTML][HTML] Childhood-onset schizophrenia: Insights from induced pluripotent stem cells
A Hoffmann, M Ziller, D Spengler - International Journal of Molecular …, 2018 - mdpi.com
Childhood-onset schizophrenia (COS) is a rare psychiatric disorder characterized by earlier
onset, more severe course, and poorer outcome relative to adult-onset schizophrenia (AOS) …
onset, more severe course, and poorer outcome relative to adult-onset schizophrenia (AOS) …
[HTML][HTML] Transcriptome dynamics of human neuronal differentiation from iPSC
The generation and use of induced pluripotent stem cells (iPSCs) in order to obtain all
differentiated adult cell morphologies without requiring embryonic stem cells is one of the …
differentiated adult cell morphologies without requiring embryonic stem cells is one of the …
[HTML][HTML] Towards bridging the translational gap by improved modeling of human nociception in health and disease
Despite numerous studies which have explored the pathogenesis of pain disorders in
preclinical models, there is a pronounced translational gap, which is at least partially caused …
preclinical models, there is a pronounced translational gap, which is at least partially caused …
TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons
Background Genetic variation in the TCF4 (transcription factor 4) gene is associated with risk
for a variety of developmental and psychiatric conditions, which includes a syndromic form of …
for a variety of developmental and psychiatric conditions, which includes a syndromic form of …
[HTML][HTML] NSC Physiological Features in Spinal Muscular Atrophy: SMN Deficiency Effects on Neurogenesis
R Adami, D Bottai - International Journal of Molecular Sciences, 2022 - mdpi.com
While the US Food and Drug Administration and the European Medicines Evaluation
Agency have recently approved new drugs to treat spinal muscular atrophy 1 (SMA1) in …
Agency have recently approved new drugs to treat spinal muscular atrophy 1 (SMA1) in …