Traumatic Brain injury-induced disturbances in mitochondrial fission-and-fusion dynamics
have been linked to the onset and propagation of neuroinflammation and …

Models for human brain-oriented research are often established on primary cultures from
rodents, which fails to recapitulate cellular specificity and molecular cues of the human …

Neural cell interventions in spinal cord injury (SCI) have focused predominantly on
transplanted multipotent neural stem/progenitor cells (NSPCs) for animal research and …

Understanding early nervous system stress response mechanisms is crucial for studying
developmental neurotoxicity and devising neuroprotective treatments. We used hiPSC …

Alzheimer's disease (AD) is a chronic neurological condition characterized by the severe
loss of cholinergic neurons. Currently, the incomplete understanding of the loss of neurons …

Both rare, high risk, loss-of-function mutations and common, low risk, genetic variants in the
CUL3 gene are strongly associated with neuropsychiatric disorders. Network analyses of …

Schizophrenia symptomatology includes negative symptoms and cognitive impairment.
Several studies have linked schizophrenia with the PDE4 family of enzymes due to their …

Excess gene dosage from chromosome 21 (chr21) causes Down syndrome (DS), spanning
developmental and acute phenotypes in terminal cell types. Which phenotypes remain …

Induced pluripotent stem cell (iPSC) technology holds promise for modeling
neurodegenerative diseases. Traditional approaches for disease modeling using animal …

In development, differentiation from a pluripotent state results in global epigenetic changes,
although the extent to which this occurs in induced pluripotent stem cell based neuronal …