Given the difficulties of obtaining diseased cells, differentiation of neurons from patient-
specific human induced pluripotent stem cells (iPSCs) with neural progenitor cells (NPCs) …

Background Trans-differentiation of human-induced pluripotent stem cells into neurons via
Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons a …

Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …

Cellular differentiation is a highly regulated process that has vast implications for the
mechanics of the cell. The interplay between differentiation induced cytoskeletal mechanical …

Integrative analysis of multiple data sets has the potential of fully leveraging the vast amount
of high throughput biological data being generated. In particular such analysis will be …

Induced pluripotent stem cell (iPSC) technology holds promise for modeling
neurodegenerative diseases. Traditional approaches for disease modeling using animal …

The implications of the early phases of human telencephalic development, involving neural
stem cells (NSCs), in the etiology of cortical disorders remain elusive. Here, we explored the …

A stable, rapid and effective neural differentiation method is essential for the clinical
applications of human embryonic stem cells (ESCs) or induced pluripotent stem cells …

Synaptic maturation is reportedly limited in human induced pluripotent stem cell (iPSC)-
derived neurons. Notably, their ability to reach postnatal-like stages and form dendritic …

Accurate quantification of intron retention levels is currently the crux for detecting and
interpreting the function of retained introns. Using both simulated and real RNA-seq …