The introduction of the E Factor in 1992 focussed attention on the problem of waste
generation, defined as everything but the desired product, in chemicals manufacture and …

The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Biocatalysis is a highly valued enabling technology for pharmaceutical research and
development as it can unlock synthetic routes to complex chiral motifs with unparalleled …

The case for a renewed focus on Nature in drug discovery is reviewed; not in terms of
natural product screening, but how and why biomimetic molecules, especially those …

With the current pressing need to rise to the ambition of net zero targets to mitigate carbon
emissions and climate change impacts, sustainable processing has never been more …

Interest in therapeutic discovery typically drives the preparation of natural product analogs,
but these undertakings contribute significant advances for synthetic chemistry as well. The …

The achievement of sufficient substrate–metal catalyst affinity is a fundamental challenge for
the development of synthetically useful C–H activation reactions of weakly coordinating …

The functionalisation of C–H bonds has been an enormous achievement in synthetic
methodology, enabling new retrosynthetic disconnections and affording simple synthetic …