Beyond the anti-PD-1/PD-L1 era: promising role of the BTLA/HVEM axis as a future target for cancer immunotherapy
C Sordo-Bahamonde, S Lorenzo-Herrero… - Molecular Cancer, 2023 - Springer
Recent introduction of monoclonal antibodies targeting immune checkpoints to harness
antitumor immunity has revolutionized the cancer treatment landscape. The therapeutic …
antitumor immunity has revolutionized the cancer treatment landscape. The therapeutic …
Realigning the LIGHT signaling network to control dysregulated inflammation
CF Ware, M Croft, GA Neil - Journal of Experimental Medicine, 2022 - rupress.org
Advances in understanding the physiologic functions of the tumor necrosis factor
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …
Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
M Ramachandran, A Vaccaro, T van de Walle… - Cancer Cell, 2023 - cell.com
Glioblastomas are aggressive brain tumors that are largely immunotherapy resistant. This is
associated with immunosuppression and a dysfunctional tumor vasculature, which hinder T …
associated with immunosuppression and a dysfunctional tumor vasculature, which hinder T …
BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM
C Battin, J Leitner, P Waidhofer-Söllner… - Frontiers in …, 2022 - frontiersin.org
The engagement of the herpesvirus entry mediator (HVEM, TNFRSF14) by the B and T
lymphocyte attenuator (BTLA) represents a unique interaction between an activating …
lymphocyte attenuator (BTLA) represents a unique interaction between an activating …
Immune checkpoint-related serum proteins and genetic variants predict outcomes of localized prostate cancer, a cohort study
Background The clinical predictors and biological mechanisms for localized prostate cancer
(PCa) outcomes remain mostly unknown. We aim to evaluate the role of serum immune …
(PCa) outcomes remain mostly unknown. We aim to evaluate the role of serum immune …
A unifying hypothesis for PNMZL and PTFL: morphological variants with a common molecular profile
J Salmeron-Villalobos, C Egan, V Borgmann… - Blood …, 2022 - ashpublications.org
Pediatric nodal marginal zone lymphoma (PNMZL) is an uncommon B-cell neoplasm
affecting mainly male children and young adults. This indolent lymphoma has distinct …
affecting mainly male children and young adults. This indolent lymphoma has distinct …
BTLA/HVEM axis induces NK cell immunosuppression and poor outcome in chronic lymphocytic leukemia
C Sordo-Bahamonde, S Lorenzo-Herrero… - Cancers, 2021 - mdpi.com
Simple Summary Chronic lymphocytic leukemia (CLL) represents the most frequent B cell
malignancy in Western countries and still remains as an incurable disease. Despite recent …
malignancy in Western countries and still remains as an incurable disease. Despite recent …
BTLA dysregulation correlates with poor outcome and diminished T cell-mediated antitumor responses in chronic lymphocytic leukemia
C Sordo-Bahamonde, S Lorenzo-Herrero… - Cancer Immunology …, 2023 - Springer
Patients with chronic lymphocytic leukemia (CLL) progressively develop marked
immunosuppression, dampening innate and adaptive-driven antitumor responses. However …
immunosuppression, dampening innate and adaptive-driven antitumor responses. However …
Immunologic signatures across molecular subtypes and potential biomarkers for sub-stratification in endometrial cancer
F Jiang, S Jiang, D Cao, M Mao, Y Xiang - International Journal of …, 2023 - mdpi.com
Current molecular classification approaches for endometrial cancer (EC) often employ
multiple testing platforms. Some subtypes still lack univocal prognostic significance …
multiple testing platforms. Some subtypes still lack univocal prognostic significance …
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160
HVEM is a TNF (tumor necrosis factor) receptor contributing to a broad range of immune
functions involving diverse cell types. It interacts with a TNF ligand, LIGHT, and …
functions involving diverse cell types. It interacts with a TNF ligand, LIGHT, and …