Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

Systemic autoinflammatory diseases (SAIDs) are a growing group of disorders caused by a
dysregulation of the innate immune system leading to episodes of systemic inflammation. In …

Abstract Background Familial Mediterranean fever, mevalonate kinase deficiency (also
known as the hyperimmunoglobulinemia D syndrome), and the tumor necrosis factor …

Background The interleukin‐1 (IL‐1) mediated systemic autoinflammatory diseases,
including the cryopyrin‐associated periodic syndromes (CAPS), tumour necrosis factor …

Monogenic autoinflammatory diseases are a group of rheumatologic disorders caused by
dysregulation in the innate immune system. The molecular mechanisms of these disorders …

The immune system protects the body against harm by inducing inflammation. During the
immune response, cells of the immune system get activated, divided and differentiated in …

Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis
(HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and …

Autoinflammatory diseases (AIDs) represent a rare and heterogeneous group of disorders
characterized by recurrent episodes of inflammation and a broad range of clinical …

In 2002, intracellular protein complexes known as the inflammasomes were discovered and
were shown to have a crucial role in the sensing of intracellular pathogen-and danger …

Periodic fever syndromes are autoinflammatory diseases. The majority present in infancy or
childhood and are characterised by recurrent episodes of fever and systemic inflammation …