A bioartificial endocrine pancreas is proposed as a future alternative to current treatment
options. Patients with insulin-secretion deficiency might benefit. This is the first systematic …

Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

Degradable hydrogels to deliver bioactive proteins represent an emerging platform for
promoting tissue repair and vascularization in various applications. However, implanting …

The human placenta is a complex organ comprised of multiple trophoblast subtypes, and
inadequate models to study the human placenta in vitro limit the current understanding of …

We have engineered polymer-based microenvironments that promote vasculogenesis both
in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly (ethyl …

A major hindrance in islet transplantation as a feasible therapeutic approach for patients
with type 1 diabetes is the insufficient oxygenation of the grafts, which results in cell death in …

Transplant of hydrogel-encapsulated allogeneic islets has been explored to reduce or
eliminate the need for chronic systemic immunosuppression by creating a physical barrier …

We report the development of a polyethylene glycol (PEG) hydrogel scaffold that provides
the advantages of conventional bulk PEG hydrogels for engineering cellular …

Human intestinal organoids (HIOs) derived from pluripotent stem cells or adult stem cell
biopsies represent a powerful platform to study human development, drug testing, and …

Hydrogel has been used in drug delivery systems because of its excellent porosity,
biocompatibility, and water retention. However, it remains challenging to medicalize …