Insufficient vascularization limits the volume and complexity of engineered tissue. The
formation of new blood vessels (neovascularization) is regulated by a complex interplay of …

Diabetes is a prevalent chronic disease affecting millions of people globally. To address this
health challenge, advanced beta cell therapy using biomaterials‐based macroscale …

The pathophysiology of type 1 diabetes is a complex process involving tightly controlled
microenvironments, a number of highly specific immune cell–islet cell interactions, and the …

The application of growth factor based therapies in regenerative medicine is limited by the
high cost, fast degradation kinetics, and the multiple functions of these molecules in the cell …

Transplantation of immuno-isolated islets is a promising strategy to restore insulin-secreting
function in patients with Type 1 diabetes. However, the clinical translation of this treatment …

Abstract Poly (lactide)(PLA) is a widely used biomaterial in many biomedical applications.
However, it is inert and therefore lacks bioactivity, which is a major drawback in addressing …

Nitric oxide (NO) is a therapeutic implicated for the treatment of diseases affecting lymphatic
tissues, which range from infectious and cardiovascular diseases to cancer. Existing …

A key parameter for the success of most cellular implants is the formation of a complete and
comprehensive intra-implant vessel network. Pre-vascularization, the generation of vessel …

Angiogenesis within the wound site is a necessary prerequisite for skin tissue regeneration
during the process of wound healing. Skin vessels provide adequate nutrients and soluble …

Over the past few decades, biomaterials have made rapid advances in tissue engineering.
In particular, there have been several studies on vascularization during skin flap …