The recent surge in multidrug-resistant pathogens combined with the diminishing antibiotic
pipeline has created a growing need to optimize the use of our existing antibiotic …

Purpose: In the present narrative review, the authors aimed to discuss the relationship
between the pharmacokinetic/pharmacodynamic (PK/PD) of antibiotics and clinical …

Background. Although a considerable amount of research has gone into the study of the role
of bactericidal versus bacteriostatic antimicrobial agents in the treatment of different …

The objective of the present study was to determine the mitochondrial toxicity mechanisms of
linezolid-related hyperlactatemia. Five patients on a long-term schedule of linezolid …

Background: Linezolid may be administered in combination with norfloxacin, gatifloxacin,
levofloxacin, moxifloxacin, and tinidazole for the treatment of various infections, such as …

Sir, Linezolid is an antibiotic with bacteriostatic activity against Gram-positive
microorganisms licensed for complicated skin and soft tissue infections and pneumonia, but …

Linezolid is the first antibiotic of a new class (oxazolidinones). It inhibits protein synthesis by
binding to the bacterial 23S ribosomal RNA of the 50S subunit, thus blocking the formation …

Conventional antibiotic dosing increases the likelihood of therapeutic failure in critically ill
patients with nosocomial pneumonia. Alternative dosing strategies, which exploit the …

Background To evaluate in vitro and in vivo efficacies of linezolid, vancomycin, and the
combination of linezolid and rifampicin against two Staphylococcus aureus strains with …

десятков тысяч известных науке видов бактерий и еще большего количества
неизвестных роль в патологии человека доказана для нескольких сотен. Но при этом …