G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

Metabolic-associated steatotic liver disease (MASLD) is closely associated with obesity.
MASLD affects over 1 billion adults globally but there are few treatment options available …

Allosteric regulation, induced by perturbations at an allosteric site topographically distinct
from the orthosteric site, is one of the most direct and efficient ways to fine-tune …

Allostery is probably the most important concept in the regulation of cellular processes.
Models to explain allostery are plenty. Each sheds light on different aspects but their entirety …

Class BG protein-coupled receptors can form dimeric complexes important for high potency
biological effects. Here, we apply pharmacological, biochemical, and biophysical techniques …

The G-protein coupled receptor (GPCR)-mediated signaling participates in almost all known
physiological processes and GPCRs have been validated as a key target family for drug …

The glucose-dependent insulinotropic polypeptide (GIPR) and glucagon-like peptide (GLP-
1R) receptor agonists are insulin secretagogues that have long been shown to improve …

Glucagon exerts effects on the mammalian heart. These effects include alterations in the
force of contraction, beating rate, and changes in the cardiac conduction system axis. The …

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors, with
many GPCRs having crucial roles in endocrinology and metabolism. Cryogenic electron …

Glucagon receptor (GCGR) agonism offers potentially greater effects on the mitigation of
hepatic steatosis. However, its underlying mechanism is not fully understood. Here, it …