Zinc and immunity: An essential interrelation
The significance of the essential trace element zinc for immune function has been known for
several decades. Zinc deficiency affects immune cells, resulting in altered host defense …
several decades. Zinc deficiency affects immune cells, resulting in altered host defense …
[HTML][HTML] Current perspectives in cancer immunotherapy
Different immunotherapeutic approaches have proved to be of significant clinical value to
many patients with different types of advanced cancer. However, we need more precise …
many patients with different types of advanced cancer. However, we need more precise …
[HTML][HTML] Tumor-derived cGAMP triggers a STING-mediated interferon response in non-tumor cells to activate the NK cell response
A Marcus, AJ Mao, M Lensink-Vasan, LA Wang… - Immunity, 2018 - cell.com
Detection of cytosolic DNA by the enzyme cGAS triggers the production of cGAMP, a second
messenger that binds and activates the adaptor protein STING, which leads to interferon …
messenger that binds and activates the adaptor protein STING, which leads to interferon …
IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced …
DA Vallera, M Felices, R McElmurry, V McCullar… - Clinical Cancer …, 2016 - AACR
Purpose: The effectiveness of NK cell infusions to induce leukemic remission is limited by
lack of both antigen specificity and in vivo expansion. To address the first issue, we …
lack of both antigen specificity and in vivo expansion. To address the first issue, we …
[HTML][HTML] The Egyptian rousette genome reveals unexpected features of bat antiviral immunity
SS Pavlovich, SP Lovett, G Koroleva, JC Guito… - Cell, 2018 - cell.com
Bats harbor many viruses asymptomatically, including several notorious for causing extreme
virulence in humans. To identify differences between antiviral mechanisms in humans and …
virulence in humans. To identify differences between antiviral mechanisms in humans and …
[HTML][HTML] Functions of natural killer cells
E Vivier, E Tomasello, M Baratin, T Walzer… - Nature …, 2008 - nature.com
Natural killer (NK) cells are effector lymphocytes of the innate immune system that control
several types of tumors and microbial infections by limiting their spread and subsequent …
several types of tumors and microbial infections by limiting their spread and subsequent …
Origin and evolution of the adaptive immune system: genetic events and selective pressures
MF Flajnik, M Kasahara - Nature Reviews Genetics, 2010 - nature.com
The adaptive immune system (AIS) in mammals, which is centred on lymphocytes bearing
antigen receptors that are generated by somatic recombination, arose approximately 500 …
antigen receptors that are generated by somatic recombination, arose approximately 500 …
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
V Béziat, LL Liu, JA Malmberg… - Blood, The Journal …, 2013 - ashpublications.org
Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like
receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a …
receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a …
NK cell recognition
LL Lanier - Annu. Rev. Immunol., 2005 - annualreviews.org
NK CELL RECOGNITION | Annual Reviews Menu Publications AZ Journal Information About
Subscribe Give Personal Register/Sign-in 0 Cart Help Journal Information Author Resource …
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Allogeneic stem cell transplantation: a historical and scientific overview
AK Singh, JP McGuirk - Cancer research, 2016 - AACR
The field of hematopoietic stem cell transplant (HSCT) has made ground-breaking progress
in the treatment of many malignant and nonmalignant conditions. It has also pioneered the …
in the treatment of many malignant and nonmalignant conditions. It has also pioneered the …