The cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins that
are produced by more than 20 species from the genera Clostridium, Streptococcus, Listeria …

Listeriolysin O (LLO) is a pore-forming toxin of the cholesterol-dependent cytolysin family
and a primary virulence factor of the gram-positive, facultative intracellular pathogen Listeria …

Pore-forming toxins are essential to the virulence of a wide variety of pathogenic bacteria.
Gardnerella vaginalis is a bacterial species associated with bacterial vaginosis (BV) and its …

Arcanobacterium pyogenes is a commensal and an opportunistic pathogen of economically
important livestock, causing diseases as diverse as mastitis, liver abscessation and …

The cholesterol-dependent cytolysins (CDCs) are a family of β-barrel pore-forming toxins
secreted by Gram-positive bacteria. These toxins are produced as water-soluble monomeric …

The pore-forming mechanism of the cholesterol-dependent cytolysins (CDCs) exhibits an
absolute requirement for membrane cholesterol. The structural elements of the CDCs that …

Cholesterol-dependent cytolysins (CDC) are pore forming toxins. A prototype of the CDC
family members is perfringolysin O (PFO), which directly binds to the cell membrane …

Pore-forming proteins containing the structurally conserved membrane attack
complex/perforin fold play an important role in immunity and host-pathogen interactions …

CD59 is a glycosylphosphatidylinositol-anchored protein that inhibits the assembly of the
terminal complement membrane attack complex (MAC) pore, whereas Streptococcus …

Three short hydrophobic loops and a conserved undecapeptide at the tip of domain 4 (D4)
of the cholesterol-dependent cytolysins (CDCs) mediate the binding of the CDC monomers …