Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side
effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically …

Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-
effects of therapies. Astrocytes are the most abundant glial cells in the central nervous …

The fact that oxaliplatin (OXL), a platinum-based chemotherapeutic drug, causes severe
neuropathy greatly limits its clinical use. This study investigated the effects of lycopene, a …

Persistent senescence seems to exert detrimental effects fostering ageing and age‐related
disorders, such as cancer. Chemotherapy is one of the most valuable treatments for cancer …

The burdensome condition of chemotherapy-induced peripheral neuropathy occurs with
various chemotherapeutics, including bortezomib, oxaliplatin, paclitaxel and vincristine. The …

Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in
vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms …

Oxaliplatin is a third-generation platinum-based chemotherapeutic drug. Although its
efficacy against colorectal cancer is well known, peripheral neuropathy that develops during …

Chemotherapy-induced peripheral neuropathy (CIPN) develops as a challenging nerve-
damaging adverse effect of anticancer drugs used in chemotherapy. The disorder may …

Morphine is a potent analgesic agent used to control acute or chronic pain. Chronic
administration of morphine results in analgesic tolerance, hyperalgesia, and other side …