Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens,
such as Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. Mastitis …

Intrathecal treatment with recombinant high‐mobility group box‐1 (rHMGB1) in naïve mice
leads to a persistent and significantly decreased hind paw withdrawal threshold to …

Neural electrode insertion trauma impedes the recording and stimulation capabilities of
numerous diagnostic and treatment avenues. Implantation leads to the activation of …

Preclinical as well as human studies indicate that melatonin is essential for a physiological
sleep state, promotes analgesia and is involved in immunometabolic signaling by regulating …

Background: Some of the current challenges and complications of cancer therapy are
chemotherapy-induced peripheral neuropathy (CIPN) and the neuropathic pain that are …

Background Oxaliplatin-induced cold allodynia is a frequent complication appearing in
patients treated with this anti-tumor drug. Since, there are no clear algorithms to overcome …

Osteoarthritis (OA), the most common form of arthritis, may be triggered by improper
secretion of circadian clock-regulated hormones, such as melatonin, thyroid-stimulating …

As cancer therapies advance and patient survival improves, there has been growing
concern about the long-term adverse effects that patients may experience following …

Chemotherapy‐induced peripheral neuropathy (CIPN) frequently occurs in cancer patients.
This side effect lowers the quality of life of patients and may cause the patients to abandon …

Hyperbaric oxygen treatment (HBOT) has been used to reduce neuropathic pain. Melatonin
and opioid receptors are involved in neuropathic pain, but it is not known if HBOT works …