Simple Summary Factors such as estrogen, progesterone, and androgen receptors, also
known as nuclear receptors, are abundantly expressed in the majority of breast cancers …

Nuclear receptors (NRs) have historically been at the forefront of cancer research, where
they are known to act as critical regulators of disease. They also serve as biomarkers for …

Drugs that inhibit estrogen receptor-α (ER) activity have been highly successful in treating
and reducing breast cancer progression in ER-positive disease. However, resistance to …

Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast
cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by …

Estrogen-dependent breast cancer is often treated with the aromatase inhibitors or estrogen
receptor (ER) antagonists. Tamoxifen as a major ER antagonist is usually used to treat those …

Purpose: CDK-activating kinase (CAK) is required for the regulation of the cell cycle and is a
trimeric complex consisting of cyclin-dependent kinase 7 (CDK7), Cyclin H, and the …

Estrogens are important endocrine hormones that control physiological functions in
reproductive organs, and play a pivotal role in the generation and progression of breast …

Abstract Liver receptor homolog-1 (LRH1) has been shown to promote tumor proliferation
and development. However, the functions of LRH1 in mediating cancer cells …

In the complex network of nuclear hormone receptors, the long non-coding RNAs (lncRNAs)
are emerging as critical determinants of hormone action. Here we investigated the …

Endocrine disrupting chemicals that are structurally similar to steroid or amine hormones
have the potential to mimic endocrine endpoints at the receptor level. However, more …