The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …

Energy deprivation is a frequent adverse event in tumors that is caused by mutations,
malperfusion, hypoxia, and nutrition deficit. The resulting bioenergetic stress leads to …

The tumor microenvironment (TME) plays an important role in neoplastic development.
Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of …

Cancer immunotherapy is a promising antitumor approach, whereas nontherapeutic side
effects, tumor microenvironment (TME) intricacy, and low tumor immunogenicity limit its …

Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …

Matrix metalloproteinases (MMPs) are an important class of enzymes in the body that
function through the extracellular matrix (ECM). They are involved in diverse …

Luteolin (3′, 4′, 5, 7-tetrahydroxyflavone), a member of the flavonoid family derived from
plants and fruits, shows a wide range of biomedical applications. In fact, due to its anti …

Nanodrug delivery system has a great application in the treatment of solid tumors by virtue of
EPR effect, though its success in clinics is still limited by its poor extravasation, small …

Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer.
The prognosis of patients with metastatic cSCC is poor emphasizing the need for new …

Oral squamous cell carcinoma (OSCC) is a prevalent form of malignant tumor, characterized
by a persistently high incidence and mortality rate. The extracellular matrix (ECM) plays a …