An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

Dementia is considered a clinical syndrome characterized by cognitive dysfunction and
memory loss. Alzheimer's disease (AD) is the most common type of dementia. AD is linked …

Alzheimer's disease (AD) is the most frequent type of dementia characterized by the
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …

γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter, playing a central role
in the regulation of cortical excitability and the maintenance of the excitatory/inhibitory (E/I) …

GABAA receptors (GABAAR) are the major players in fast inhibitory neurotransmission in the
central nervous system (CNS). Regulation of GABAAR trafficking and the control of their …

Alzheimer's disease (AD) is the commonest neurodegenerative disease with slow
progression. Pieces of evidence suggest that the GABAergic system is impaired in the early …

The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The
main features of neurodegenerative diseases have been related with cellular and molecular …

Neurological diseases including Alzheimer's, Huntington's disease, Parkinson's disease,
Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are …

The hippocampus is a primary area for contextual memory, known to process spatiotemporal
information within a specific episode. Long-term strengthening of glutamatergic transmission …

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the nervous
system. Previous studies have shown fluctuations in expression levels of GABA signaling …