Abstract γ-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter in the
mammalian brain and has been found to play an important role in the pathogenesis or the …

The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the
modulation of neuronal excitability, and a disruption of GABAergic transmission contributes …

Sedatives promote calmness or sleepiness during surgery or severely stressful events. In
addition, depression is a mental health issue that negatively affects emotional well-being. A …

Chronic insomnia occurs in~ 10% of the general population and has numerous negative
health effects. The recommended first line treatment of cognitive behavior therapy for …

Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the
global disease burden, contributes substantially to societal and economic costs, and leads …

Increased use of benzodiazepines in adolescents have been reported, with alprazolam
(ALP) being the most abused. Drug abuse during adolescence can induce changes with …

Pharmacotherapy for neuropsychiatric disorders, such as anxiety and depression, has been
characterized by significant inter-individual variability in drug response and the development …

Diazepam and lorazepam are two benzodiazepine drugs widely prescribed as
antidepressants and antiepileptics. A straightforward and time-save dispersive micro solid …

Drugs that modulate the GABAA receptor are widely used in clinical practice for both the
long-term management of epilepsy and emergency seizure control. In addition to older …

Critical for brain development, neurodevelopmental and network disorders, the GABRA1
gene encodes for the α1 subunit, an abundantly and developmentally expressed subunit of …