Myocardial ischemia-reperfusion injury and the influence of inflammation

M Algoet, S Janssens, U Himmelreich, W Gsell… - Trends in cardiovascular …, 2023 - Elsevier
Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to
ischemia in the corresponding myocardial territory which generally results in myocardial …

[HTML][HTML] Cells of the immune system in cardiac remodeling: main players in resolution of inflammation and repair after myocardial infarction

I Kologrivova, M Shtatolkina, T Suslova… - Frontiers in …, 2021 - frontiersin.org
The burden of heart failure (HF), developing after myocardial infarction MI, still represents a
major issue in clinical practice. Failure of appropriate resolution of inflammation during post …

Macrophages in cardiac remodelling after myocardial infarction

J Yap, J Irei, J Lozano-Gerona, S Vanapruks… - Nature Reviews …, 2023 - nature.com
Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Immune cells and immunotherapy for cardiac injury and repair

JG Rurik, H Aghajanian, JA Epstein - Circulation research, 2021 - Am Heart Assoc
Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

[HTML][HTML] Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

C Li, X Xu, S Wei, P Jiang, L Xue… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Macrophages are the most important phagocytes in vivo. However, the tumor
microenvironment can affect the function and polarization of macrophages and form tumor …

Nanowired human cardiac organoid transplantation enables highly efficient and effective recovery of infarcted hearts

Y Tan, RC Coyle, RW Barrs, SE Silver, M Li… - Science …, 2023 - science.org
Human cardiac organoids hold remarkable potential for cardiovascular disease modeling
and human pluripotent stem cell–derived cardiomyocyte (hPSC-CM) transplantation. Here …

[HTML][HTML] Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine

L Gao, F Qiu, H Cao, H Li, G Dai, T Ma, Y Gong… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Clinical application of mesenchymal stem cells (MSCs) and MSC-derived
exosomes (MSC-Exos) to alleviate myocardial ischemia/reperfusion (I/R) injury is …

Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?

M Sweeney, B Corden, SA Cook - EMBO molecular medicine, 2020 - embopress.org
Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Role of inflammatory chemokines in hypertension

TP Mikolajczyk, P Szczepaniak, F Vidler… - Pharmacology & …, 2021 - Elsevier
Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

[HTML][HTML] Macrophage polarization in cardiac tissue repair following myocardial infarction

Y Kim, S Nurakhayev, A Nurkesh… - International journal of …, 2021 - mdpi.com
Cardiovascular disease is the leading cause of mortality and morbidity around the globe,
creating a substantial socio-economic burden as a result. Myocardial infarction is a …