Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

The dynamic turnover of actin filaments (F-actin) controls cellular motility in eukaryotes and
is coupled to changes in the F-actin nucleotide state,–. It remains unclear how F-actin …

ATP-hydrolysis-coupled actin polymerization is a fundamental mechanism of cellular force
generation,–. In turn, force, and actin filament (F-actin) nucleotide state regulate actin …

The barbed and pointed ends of the actin filament (F-actin) are the sites of growth and
shrinkage and the targets of capping proteins that block subunit exchange, including CapZ …

Generating force and movement is essential for the functions of cells and organisms. A
variety of molecular motors that can move on tracks within cells have evolved to serve this …

Arp2/3 complex nucleates branched actin filaments that provide pushing forces to drive
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …

Actin isoforms organize into distinct networks that are essential for the normal function of
eukaryotic cells. Despite a high level of sequence and structure conservation, subtle …

The release of inorganic phosphate (Pi) from actin filaments constitutes a key step in their
regulated turnover, which is fundamental to many cellular functions. The mechanisms …

We reconstructed the structure of actin filament branch junctions formed by fission yeast
Arp2/3 complex at 3.5 Å resolution from images collected by electron cryo-microscopy …