Getting the “kill” into “shock and kill”: strategies to eliminate latent HIV
Y Kim, JL Anderson, SR Lewin - Cell host & microbe, 2018 - cell.com
Despite the success of antiretroviral therapy (ART), there is currently no HIV cure and
treatment is life long. HIV persists during ART due to long-lived and proliferating latently …
treatment is life long. HIV persists during ART due to long-lived and proliferating latently …
Monocytes and macrophages as viral targets and reservoirs
E Nikitina, I Larionova, E Choinzonov… - International journal of …, 2018 - mdpi.com
Viruses manipulate cell biology to utilize monocytes/macrophages as vessels for
dissemination, long-term persistence within tissues and virus replication. Viruses enter cells …
dissemination, long-term persistence within tissues and virus replication. Viruses enter cells …
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Human cancers are complex ecosystems composed of cells with distinct phenotypes,
genotypes, and epigenetic states, but current models do not adequately reflect tumor …
genotypes, and epigenetic states, but current models do not adequately reflect tumor …
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy
Chromosomal integration of genome-intact HIV-1 sequences into the host genome creates a
reservoir of virally infected cells that persists throughout life, necessitating indefinite …
reservoir of virally infected cells that persists throughout life, necessitating indefinite …
Curing HIV: seeking to target and clear persistent infection
Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
Defective proviruses rapidly accumulate during acute HIV-1 infection
KM Bruner, AJ Murray, RA Pollack, MG Soliman… - Nature medicine, 2016 - nature.com
Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable
levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4+ T cells in a latent form …
levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4+ T cells in a latent form …
The mTOR complex controls HIV latency
Summary A population of CD4 T lymphocytes harboring latent HIV genomes can persist in
patients on antiretroviral therapy, posing a barrier to HIV eradication. To examine cellular …
patients on antiretroviral therapy, posing a barrier to HIV eradication. To examine cellular …
Elimination of HIV-1-infected cells by broadly neutralizing antibodies
T Bruel, F Guivel-Benhassine, S Amraoui… - Nature …, 2016 - nature.com
The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for
suppressing viraemia, through mechanisms which remain poorly understood. Here, we …
suppressing viraemia, through mechanisms which remain poorly understood. Here, we …
Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1
Massive research efforts are now underway to develop a cure for HIV infection, allowing
patients to discontinue lifelong combination antiretroviral therapy (ART). New latency …
patients to discontinue lifelong combination antiretroviral therapy (ART). New latency …
Analytical and numerical study of the HIV‐1 infection of CD4+ T‐cells conformable fractional mathematical model that causes acquired immunodeficiency syndrome …
In this paper, we introduce a numerical and analytical study of the HIV‐1 infection of CD4+ T‐
cells conformable fractional mathematical model. This model is studied analytically by …
cells conformable fractional mathematical model. This model is studied analytically by …