In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

Microglia are resident macrophages of the CNS that are involved in its development,
homeostasis and response to infection and damage. Microglial activation is a common …

Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …

Microglia are activated in many neurological diseases and have been suggested to play an
important role in the development of affective disorders including major depression. To …

Myelination is an essential process that consists of the ensheathment of axons by myelin. In
the central nervous system (CNS), myelin is synthesized by oligodendrocytes. The …

Microglia are highly plastic immune cells which exist in a continuum of activation states. By
shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which …

Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …

Inflammation of the nervous system (neuroinflammation) is now recognized as a hallmark of
virtually all neurological disorders. In neuroinflammatory conditions such as multiple …