Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune
cell types and are generally categorized into either of two functionally contrasting subtypes …

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis …

Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …

Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense
against certain pathogen invasions. The deregulation of necroptosis is also a key factor of …

Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and
cause neurological symptoms. Here we describe structural changes in cerebral small …

Macrophages are phagocytes that serve as a first line of defense against pathogenic insults
to tissues. These innate immune cells mount proinflammatory responses to pathogens and …

Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …