Publisher Summary The chapter describes the understanding of the physics and physical
chemistry of sickle cell hemoglobin polymerization in solutions and in red cells. The …

Sickle hemoglobin polymerization commences with a striking latency period, called a “delay
time” followed by abrupt polymer formation. The delay time is exceedingly concentration …

To understand the physical basis of the wide variety of shapes of deoxygenated red cells
from patients with sickle cell anemia, we have measured the formation rate and volume …

In this work, we utilized a parameterization model of ektacytometry to quantify the bulk
rigidity of the rigid red blood cell (RBC) population in sickle cell disease (SCD) patients …

Pathogenesis in sickle cell disease depends on polymerization and gelation of
deoxyhemoglobin S. Under the double nucleation model, polymerization is initiated by …

The polymerization of sickle hemoglobin involves the assembly of 14 stranded fibers, which
are found in dense multibranched arrays (Briehl, 1995; White & Heagan, 1970) called …

We have used differential polarization imaging microscopy to measure the amount and
orientation of aligned sickle hemoglobin polymer in quickly deoxygenated sickle red blood …

Sickle cell disease arises from a genetic mutation of one amino acid in each of the two
hemoglobin β chains, leading to the polymerization of hemoglobin in the red cell upon …

The polymerization of sickle hemoglobin occurs by the same mechanisms in solutions and
in cells, and involves the formation of 14 stranded fibers from hemoglobin molecules which …

The gelation of sickle hemoglobin includes the formation of spherulitic arrays of polymers,
known as polymer domains, which are an intrinsic result of the polymer formation …