Cancer is a complex disease whose outcome depends largely on the cross-talk between the
tumor and its microenvironment. Here, we review the evolution of the field of tumor …

Colorectal cancer (CRC) is a heterogeneous disease with one of the highest rates of
incidence and mortality among cancers worldwide. Understanding the CRC tumor …

In recent years, several newly identified T helper (TH) cell subsets, such as TH9, TH17, and
TH22 cells, and their respective cytokine products, IL-9, IL-17, and IL-22, have been …

Solid tumors are infiltrated by stroma cells including macrophages and these cells can affect
tumor growth, metastasis and angiogenesis. We have investigated the effects of conditioned …

Background: A decrease in the number of tissue eosinophils is known to reflect the
malignancy potential of neoplastic lesions and even prognosis. Increased levels of the …

The development of colorectal cancer (CRC) is not only determined by transformed cells per
se, but also by factors existing in their immune microenvironment. Accumulating scientific …

Understanding the interactions between tumors and the host immune system holds great
promise to uncover biomarkers for targeted therapies, predict the prognosis of patients and …

A unique and fundamental characteristic of malignant neoplastic cells is their ability to
invade other tissues and metastasise. The first step in this process is the dissociation of …

ST2 (also known as IL1RL1) is the critical functional receptor for interleukin (IL)-33 in
stimulating regulatory T cell (Treg) expansion and function in physiological and pathological …

Objectives T regulatory cells (Tregs) play a critical important role for the occurrence and
development of human tumors. Most human colorectal cancers (CRCs) develop from the …