Innate immune responses to RNA: sensing and signaling

X Luan, L Wang, G Song, W Zhou - Frontiers in Immunology, 2024 - frontiersin.org
Nucleic acids are among the most essential PAMPs (pathogen-associated molecular
patterns). Animals have evolved numerous sensors to recognize nucleic acids and trigger …

[HTML][HTML] Enhancing Vaccine Efficacy and Stability: A Review of the Utilization of Nanoparticles in mRNA Vaccines

N Parvin, SW Joo, TK Mandal - Biomolecules, 2024 - mdpi.com
The development of vaccines has entered a new era with the advent of nanotechnology,
particularly through the utilization of nanoparticles. This review focuses on the role of …

[HTML][HTML] Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles

VL Sedlmayr, S Schobesberger, S Spitz, P Ertl… - European Journal of …, 2024 - Elsevier
Neutral and positively charged archaeal ether lipids (AEL) have been studied for their
utilization as novel delivery systems for pDNA, showing efficient immune response with a …

Innate and Adaptive Immune Parameters following mRNA Vaccination in Mice

SR Bonam, NC Hazell, MJ Mathew, Y Liang, X Zhang… - Vaccines, 2024 - mdpi.com
The COVID-19 pandemic has raised the standard regarding the current vaccine
development pace, as several messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines …

The dawn of a new Era: mRNA vaccines in colorectal cancer immunotherapy

J Song, Y Zhang, C Zhou, J Zhan, X Cheng… - International …, 2024 - Elsevier
Colorectal cancer (CRC) is a typical cancer that accounts for 10% of all new cancer cases
annually and nearly 10% of all cancer deaths. Despite significant progress in current …

Can the Revolution in mRNA-Based Vaccine Technologies Solve the Intractable Health Issues of Current Ruminant Production Systems?

TJ Mahony, TE Briody, SC Ommeh - Vaccines, 2024 - mdpi.com
To achieve the World Health Organization's global Sustainable Development Goals,
increased production of high-quality protein for human consumption is required while …

[HTML][HTML] Recent Developments of Vaccines as a Precision Medicine Approach to Cancer Immunotherapy

JF Murphy - Cancer Screening and Prevention, 2024 - xiahepublishing.com
Precision medicine involves tailoring an individual's genes or proteins to prevent, diagnose,
or treat diseases such as cancer. Given the recent advances in cancer immunotherapy …

Immunogenicity and Protection of the mXCL1-PyCSP Fusion Protein Prime-and-Trap DNA Vaccine in a Murine Malaria Immunization/Challenge Model

K Boey - 2024 - search.proquest.com
Malaria is a life-threatening parasitic disease caused by Plasmodium spp. and is transmitted
by female Anopheles spp. mosquitoes. Annually, there are nearly 250 million cases …