Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-
forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1-and …

Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in
systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from …

Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers.
Pyroptosis, a newly discovered programmed cell death, was recently reported to be …

Regulated necrosis has been reported to exert an important role in the pathogenesis of
various diseases, including renal ischemia-reperfusion (I/R) injury. Damage to renal tubular …

In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI)
and AKI to chronic kidney disease (CKD) progression has been revisited as our …