Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

Abstract Chagas disease and Human African Trypanosomiasis (HAT) are caused by
Trypanosoma cruzi and T. brucei parasites, respectively. Cruzain (CRZ) and Rhodesain …

Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …

Continuing our screening program for novel anti-parasite compounds, we synthesized
seven 1, 4-naphthoquinones coupled to 1, 2, 3-triazoles, five nor-β-lapachone-based 1, 2, 3 …

Naphthoquinoidal compounds are of great interest in medicinal chemistry. In recent years,
several synthetic routes have been developed to obtain bioactive molecules derived from …

This review involves the chemistry and biochemistry of lapachol, β-lapachone and lawsone,
examples of bioactive natural products that still being under biological evaluation and …

Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi. It has high
mortality as well as morbidity rates and usually affects the poorer sections of the population …

Natural products comprise valuable sources for new antiparasitic drugs. Here we tested the
effects of a novel β–lapachone derivative on Trypanosoma cruzi parasite survival and …

In the present work, theophylline immobilized on superparamagnetic Fe3O4@ SiO2
nanoparticles were prepared via a multistep method and was fully characterized by means …