Non-natural folded polymers (foldamers) display considerable versatility, and the design of
such molecules is of great current interest. In this respect, peptidic foldamers are perhaps …

Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides
that fold into well-defined three-dimensional structures. They offer the chemical biologist a …

For more than a decade now, a search for answers to the following two questions has taken
us on a new and exciting journey into the world of β-and γ-peptides: What happens if the …

The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

hDM2 is recognized in vivo by a short α-helix within the p53 trans-activation domain
(p53AD). Disruption of the p53⊙ hDM2 interaction is an important goal for cancer therapy. A …

HIV-1 TAR RNA is the binding site of the viral protein Tat, the trans-activator of the HIV-1
LTR. It is present at the 5'end of all HIV-1 spliced and unspliced mRNAs in the nucleus as …

We became interested several years ago in exploring whether 14-helical β-peptide
foldamers could bind protein surfaces and inhibit protein–protein interactions, and if so …

Naturally occurring peptides serve important functions as enzyme inhibitors, hormones,
neurotransmitters, and immunomodulators in many physiological processes including …

Highlights•A range of functionally and structurally unrelated proteins form amyloid.•Toxic
intermediates remain elusive, making their targeting a significant challenge.•Design and …

β-Amino acids are important synthetic targets due to their presence in a wide variety of
natural products, pharmaceutical agents, and mimics of protein structural motifs. While β …