[HTML][HTML] Chemokines and chemokine receptors as promising targets in rheumatoid arthritis

MA Murayama, J Shimizu, C Miyabe, K Yudo… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …

[HTML][HTML] The protective activity of genistein against bone and cartilage diseases

Z Wu, L Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown
various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and …

[HTML][HTML] Understanding the function of the GABAergic system and its potential role in rheumatoid arthritis

Y Shan, J Zhao, Y Zheng, S Guo, SJ Schrodi… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a highly disabling chronic autoimmune disease. Multiple factors
contribute to the complex pathological process of RA, in which an abnormal autoimmune …

Cholesterol biases the conformational landscape of the chemokine receptor CCR3: A MAS SSNMR-filtered molecular dynamics study

EJ van Aalst, CJ McDonald… - Journal of Chemical …, 2023 - ACS Publications
Cholesterol directs the pathway of ligand-induced G protein-coupled receptor (GPCR) signal
transduction. The GPCR C–C motif chemokine receptor 3 (CCR3) is the principal …

[HTML][HTML] Exploring the Therapeutic Potential of Ammodaucus leucotrichus Seed Extracts: A Multi-Faceted Analysis of Phytochemical Composition, Anti-Inflammatory …

C Djehiche, N Benzidane, H Djeghim, M Tebboub… - Pharmaceuticals, 2024 - mdpi.com
Ammodaucus leucotrichus exhibits promising pharmacological activity, hinting at anti-
inflammatory and anti-arthritic effects. This study investigated seed extracts from …

[HTML][HTML] Role of the granzyme family in rheumatoid arthritis: Current Insights and future perspectives

Y Zheng, J Zhao, Y Shan, S Guo, SJ Schrodi… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic
inflammation that affects synovial tissues of multiple joints. Granzymes (Gzms) are serine …

[HTML][HTML] Role of signaling lymphocytic activation molecule family of receptors in the pathogenesis of rheumatoid arthritis: insights and application

Y Zheng, J Zhao, M Zhou, K Wei, P Jiang… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
and joint damage. The signaling lymphocytic activation molecule (SLAMF) family of …

[HTML][HTML] The commonness in immune infiltration of rheumatoid arthritis and atherosclerosis: Screening for central targets via microarray data analysis

Z Wang, Q Xia, W Su, M Zhang, Y Gu, J Xu… - Frontiers in …, 2022 - frontiersin.org
Background Although increasing evidence has reported an increased risk of atherosclerosis
(AS) in rheumatoid arthritis (RA), the communal molecular mechanism of this phenomenon …

[HTML][HTML] Single-cell characterisation of tissue homing CD4+ and CD8+ T cell clones in immune-mediated refractory arthritis

D Bhattacharya, J Theodoropoulos, K Nurmi… - Molecular …, 2024 - Springer
Background Immune-mediated arthritis is a group of autoinflammatory diseases, where the
patient's own immune system attacks and destroys synovial joints. Sustained remission is …

[HTML][HTML] Identification of immunological characterization and Anoikis-related molecular clusters in rheumatoid arthritis

J Zhao, K Wei, Y Shi, P Jiang, L Xu, C Chang… - Frontiers in Molecular …, 2023 - frontiersin.org
Objective: To investigate the potential association between Anoikis-related genes, which are
responsible for preventing abnormal cellular proliferation, and rheumatoid arthritis (RA) …