Acquired and intrinsic gemcitabine resistance in pancreatic cancer therapy: Environmental factors, molecular profile and drug/nanotherapeutic approaches
A high number of cancer patients around the world rely on gemcitabine (GEM) for
chemotherapy. During local metastasis of cancers, surgery is beneficial for therapy, but …
chemotherapy. During local metastasis of cancers, surgery is beneficial for therapy, but …
Genomics of high-grade neuroendocrine neoplasms: well-differentiated neuroendocrine tumor with high-grade features (G3 NET) and neuroendocrine carcinomas …
S Uccella, S La Rosa, J Metovic, D Marchiori… - Endocrine …, 2021 - Springer
High-grade neuroendocrine neoplasms (HG-NENs) are clinically aggressive diseases, the
classification of which has recently been redefined. They now include both poorly …
classification of which has recently been redefined. They now include both poorly …
Expanding therapeutic opportunities for extrapulmonary neuroendocrine carcinoma
M Frizziero, E Kilgour, KL Simpson, DG Rothwell… - Clinical Cancer …, 2022 - AACR
Poorly differentiated neuroendocrine carcinomas (PD-NEC) are rare cancers garnering
interest as they become more commonly encountered in the clinic. This is due to improved …
interest as they become more commonly encountered in the clinic. This is due to improved …
Potent molecular-targeted therapies for gastro-entero-pancreatic neuroendocrine carcinoma
Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine
differentiation, can arise in various organs. NENs have been divided into well-differentiated …
differentiation, can arise in various organs. NENs have been divided into well-differentiated …
Tumor organoids: applications in cancer modeling and potentials in precision medicine
H Xu, D Jiao, A Liu, K Wu - Journal of hematology & oncology, 2022 - Springer
Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor
heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors …
heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors …
Autophagy: a key player in pancreatic cancer progression and a potential drug target
J Gillson, YS Abd El-Aziz, LYW Leck, PJ Jansson… - Cancers, 2022 - mdpi.com
Simple Summary With the mortality rate of pancreatic cancer predicted to rise over the
coming years, it is essential that effective treatment strategies are developed as soon as …
coming years, it is essential that effective treatment strategies are developed as soon as …
Gastroenteropancreatic neuroendocrine neoplasms G3: Novel insights and unmet needs
M Shi, Z Fan, J Xu, J Yang, Y Li, C Gao, P Su… - … et Biophysica Acta (BBA …, 2021 - Elsevier
According to the 2019 WHO pathology grading system, high-grade gastroenteropancreatic
neuroendocrine neoplasms (GEP-NENs) can be divided into well differentiated …
neuroendocrine neoplasms (GEP-NENs) can be divided into well differentiated …
Radiomics combined with multiple machine learning algorithms in differentiating pancreatic ductal adenocarcinoma from pancreatic neuroendocrine tumor: more …
T Zhang, Y Xiang, H Wang, H Yun, Y Liu… - Journal of Clinical …, 2022 - mdpi.com
The aim of this study was to assess the diagnostic ability of radiomics combined with
multiple machine learning algorithms to differentiate pancreatic ductal adenocarcinoma …
multiple machine learning algorithms to differentiate pancreatic ductal adenocarcinoma …
Identification of novel therapeutic target and prognostic biomarker in matrix metalloproteinase gene family in pancreatic cancer
H Luan, L Jian, Y Huang, Y Guo, L Zhou - Scientific Reports, 2023 - nature.com
Matrix metalloproteinases (MMPs) play an essential role in various physiological events.
Recent studies have revealed its carcinogenic effect in malignancies. However, the different …
Recent studies have revealed its carcinogenic effect in malignancies. However, the different …
EZH2 as a potential therapeutic target for gastrointestinal cancers
M Hashemi, N Nazdari, G Gholamiyan… - … -Research and Practice, 2023 - Elsevier
Gastrointestinal (GI) cancers continue to be a major cause of mortality and morbidity
globally. Understanding the molecular pathways associated with cancer progression and …
globally. Understanding the molecular pathways associated with cancer progression and …