Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage,
which plays both structural and functional roles in bacteria. Trehalose can be synthesized …

Chickpea plant root colonizing bacteria Mesorhizobium ciceri Ca181 promotes plant growth
and development through symbiotic association with root nodules. The potentially beneficial …

Many computational models for analyzing and predicting cell physiology rely on in vitro data
collected in dilute and controlled buffer solutions. However, this can mislead models …

The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) causes infections
that are difficult to treat, which is due to the bacterial resistance to antibiotics. We herein …

Abstract Background Trehalose-6-phosphate phosphatase (TPP6) is a key enzyme in the
trehalose biosynthesis pathway. The accumulation of TPP6 inside the body is harmful to the …

Quorum sensing (QS) is one of the key virulence factors in Pseudomonas aeruginosa and
causes recalcitrant infections. Multi-drug resistance and biofilm formation seem to be …

We report the functional and structural characterization of trehalose-6-phosphate
phosphatase (TPP), from the Gram-negative bacterium B. pseudomallei that causes …

Protein-based drug discovery strategies have the distinct advantage of providing insights
into the molecular mechanisms of chemical effectors. Currently, there are no known …

Trehalose-6-phosphate phosphatase (T6PP) catalyzes the dephosphorylation of trehalose 6-
phosphate (T6P) to the disaccharide trehalose. The enzyme is not present in mammals but …

The trehalose biosynthesis pathway has recently received attention for therapeutic
intervention combating infectious diseases caused by bacteria, helminths or fungi …